Carboplatin hypersensitivity presenting as coronary vasospasm - a case report Journal Articles

abstract

• A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion. This reaction was considered to fit with coronary vasospasm. Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.

authors

• Chasen, Martin
• Ebrahim, Iftikar

status

• published 

publication date

• November 1, 2002

has subject area

• 1115 Pharmacology and Pharmaceutical Sciences (FoR)
• Aged (MeSH)
• Antineoplastic Combined Chemotherapy Protocols (MeSH)
• Aortic Valve Stenosis (MeSH)
• Calcinosis (MeSH)
• Carboplatin (MeSH)
• Coronary Vasospasm (MeSH)
• Cyclophosphamide (MeSH)
• Drug Hypersensitivity (MeSH)
• Electroencephalography (MeSH)
• Female (MeSH)
• Humans (MeSH)
• Infusions, Intravenous (MeSH)
• Oncology & Carcinogenesis (Science Metrix)
• Ovarian Neoplasms (MeSH)
• Pleural Effusion, Malignant (MeSH)

published in

• Cancer Chemotherapy and Pharmacology  Journal

keywords

• Aged
• Antineoplastic Combined Chemotherapy Protocols
• Aortic Valve Stenosis
• Calcinosis
• Carboplatin
• Coronary Vasospasm
• Cyclophosphamide
• Drug Hypersensitivity
• Electroencephalography
• Female
• Humans
• Infusions, Intravenous
• Ovarian Neoplasms
• Pleural Effusion, Malignant

Digital Object Identifier (DOI)

• 10.1007/s00280-002-0518-3

PubMed ID

• 12439602

start page

• 429

end page

• 431

volume

• 50

issue

• 5