Preparation of synthons for carborane containing macromolecules Conferences

abstract

• AbstractThe modification of para‐carborane with appropriate functionalities for incorporation within a dendrimer framework was accomplished by functionalizing the carbon centers with protected alcohol and free acid groups. These compounds are excellent candidates for utilization as functional linkers between two generations of an aliphatic polyester dendrimer structure. Future assembly of these structures will result in dendritic macromolecules containing carboranes within their interior and will be enveloped by hydrophilic groups (hydroxyls) to maintain their water solubility and biocompatibility. These structures have potential applications in Boron Neutron Capture Therapy and Synovectomy. Additionally, carboranes were coupled to polymerizable acrylate structures, and it was shown that the resulting carborane monomers could be polymerized using living free‐radical polymerization techniques.

authors

• Parrott, Matthew C
• Marchington, Erin B
• Valliant, John F
• Adronov, Alex

status

• published 

publication date

• July 2003

has subject area

• 0303 Macromolecular and Materials Chemistry (FoR)

published in

• Macromolecular Symposia  Journal

presented at event

• Symposium on Metal- and Metalloid-Containing Macromolecules  Conference

keywords

• 2,2-BIS(HYDROXYMETHYL)PROPIONIC ACID
• CHEMISTRY
• DENDRIMERS
• DRUG-DELIVERY APPLICATIONS
• NEUTRON-CAPTURE THERAPY
• POLYESTER DENDRITIC SYSTEMS
• Physical Sciences
• Polymer Science
• Science & Technology
• atom transfer radical polymerization
• carboranes
• dendrimers
• drug delivery
• polymers

Digital Object Identifier (DOI)

• 10.1002/masy.200390161

start page

• 201

end page

• 211

volume

• 196

issue

• 1