Guidelines for surfactant replacement therapy in neonates Journal Articles

abstract

• AbstractSurfactant replacement therapy (SRT) plays a pivotal role in the management of neonates with respiratory distress syndrome (RDS) because it improves survival and reduces respiratory morbidities. With the increasing use of noninvasive ventilation as the primary mode of respiratory support for preterm infants at delivery, prophylactic surfactant is no longer beneficial. For infants with worsening RDS, early rescue surfactant should be provided. While the strategy to intubate, give surfactant, and extubate (INSURE) has been widely accepted in clinical practice, newer methods of noninvasive surfactant administration, using thin catheter, laryngeal mask airway, or nebulization, are being adopted or investigated. Use of SRT as an adjunct for conditions other than RDS, such as meconium aspiration syndrome, may be effective based on limited evidence.

authors

• Ng, Eu-gene
• Shah, Vibhuti

status

• published 

publication date

• February 1, 2021

has subject area

• 1114 Paediatrics and Reproductive Medicine (FoR)

published in

• Paediatrics and Child Health  Journal

keywords

• Bronchopulmonary dysplasia
• Neonates
• Noninvasive ventilation
• Preterm infants
• Respiratory distress syndrome
• Surfactant

Digital Object Identifier (DOI)

• 10.1093/pch/pxaa116

start page

• 35

end page

• 41

volume

• 26

issue

• 1