The unique characteristics of COVID-19 coagulopathy Journal Articles

abstract

• AbstractThrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC), with CAC usually showing increased D-dimer and fibrinogen levels but initially minimal abnormalities in prothrombin time and platelet count. Venous thromboembolism and arterial thrombosis are more frequent in CAC compared to SIC/DIC. Clinical and laboratory features of CAC overlap somewhat with a hemophagocytic syndrome, antiphospholipid syndrome, and thrombotic microangiopathy. We summarize the key characteristics of representative coagulopathies, discussing similarities and differences so as to define the unique character of CAC.

authors

• Iba, Toshiaki
• Levy, Jerrold H
• Connors, Jean Marie
• Warkentin, Ted
• Thachil, Jecko
• Levi, Marcel

status

• published 

publication date

• December 2020

has subject area

• 11 Medical and Health Sciences (FoR)
• Betacoronavirus (MeSH)
• Blood Coagulation Disorders (MeSH)
• Blood Coagulation Tests (MeSH)
• COVID-19 (MeSH)
• Coronavirus Infections (MeSH)
• Emergency & Critical Care Medicine (Science Metrix)
• Humans (MeSH)
• Inflammation Mediators (MeSH)
• Pandemics (MeSH)
• Platelet Aggregation (MeSH)
• Pneumonia, Viral (MeSH)
• SARS-CoV-2 (MeSH)

published in

• Critical Care  Journal

keywords

• Antiphospholipid syndrome
• Betacoronavirus
• Blood Coagulation Disorders
• Blood Coagulation Tests
• COVID-19
• Coagulopathy
• Coronavirus Infections
• Disseminated intravascular coagulation
• Hemophagocytic syndrome
• Humans
• Inflammation Mediators
• Pandemics
• Platelet Aggregation
• Pneumonia, Viral
• SARS-CoV-2
• Thrombotic microangiopathy

Digital Object Identifier (DOI)

• 10.1186/s13054-020-03077-0

start page

• 360

volume

• 24

issue

• 1