On the Road to Bacterial Cell Death Journal Articles

abstract

• How do antibiotics actually work? Although the primary cellular targets of many antimicrobial agents have been identified, the downstream events leading to bacterial cell death remain unclear. In this issue, Kohanski et al. (2007) provide evidence that the production of reactive oxygen species is a shared mechanism of cell death initiated by bactericidal antibiotics.

authors

• Wright, Gerard

status

• published 

publication date

• September 2007

has subject area

• 06 Biological Sciences (FoR)
• 11 Medical and Health Sciences (FoR)
• Ampicillin (MeSH)
• Anti-Bacterial Agents (MeSH)
• Carbon-Sulfur Lyases (MeSH)
• Cell Death (MeSH)
• Citric Acid Cycle (MeSH)
• DNA Damage (MeSH)
• DNA, Bacterial (MeSH)
• Developmental Biology (Science Metrix)
• Escherichia coli (MeSH)
• Escherichia coli Proteins (MeSH)
• Ferrous Compounds (MeSH)
• Gene Expression Regulation, Bacterial (MeSH)
• Hydrogen Peroxide (MeSH)
• Hydroxyl Radical (MeSH)
• Kanamycin (MeSH)
• Membrane Proteins (MeSH)
• Microbial Viability (MeSH)
• Mutation (MeSH)
• NAD (MeSH)
• Norfloxacin (MeSH)
• Oxidative Stress (MeSH)
• Rec A Recombinases (MeSH)
• Staphylococcus aureus (MeSH)
• Time Factors (MeSH)

published in

• Cell  Journal

keywords

• Ampicillin
• Anti-Bacterial Agents
• Carbon-Sulfur Lyases
• Cell Death
• Citric Acid Cycle
• DNA Damage
• DNA, Bacterial
• Escherichia coli
• Escherichia coli Proteins
• Ferrous Compounds
• Gene Expression Regulation, Bacterial
• Hydrogen Peroxide
• Hydroxyl Radical
• Kanamycin
• Membrane Proteins
• Microbial Viability
• Mutation
• NAD
• Norfloxacin
• Oxidative Stress
• Rec A Recombinases
• Staphylococcus aureus
• Time Factors

Digital Object Identifier (DOI)

• 10.1016/j.cell.2007.08.023

PubMed ID

• 17803902

start page

• 781

end page

• 783

volume

• 130

issue

• 5