Direct Microbicidal Activity of Cytotoxic T-Lymphocytes Journal Articles

abstract

• Cytotoxic T-lymphocytes (CTL) are famous for their ability to kill tumor, allogeneic and virus-infected cells. However, an emerging literature has now demonstrated that CTL also possess the ability to directly recognize and kill bacteria, parasites, and fungi. Here, we review past and recent findings demonstrating the direct microbicidal activity of bothCD4+andCD8+CTL against various microbial pathogens. Further, this review will outline what is known regarding the mechanisms of direct killing and their underlying signalling pathways.

authors

• Oykhman, Paul
• Mody, Christopher H

status

• published 

publication date

• 2010

has subject area

• 06 Biological Sciences (FoR)
• 08 Information and Computing Sciences (FoR)
• 10 Technology (FoR)
• Animals (MeSH)
• Bacteria (MeSH)
• CD4 Antigens (MeSH)
• CD8 Antigens (MeSH)
• Candida albicans (MeSH)
• Cryptococcus neoformans (MeSH)
• Cytotoxicity, Immunologic (MeSH)
• Schistosoma (MeSH)
• Signal Transduction (MeSH)
• T-Lymphocytes, Cytotoxic (MeSH)
• Toxoplasma (MeSH)

published in

• BioMed Research International  Journal

keywords

• Animals
• Bacteria
• CD4 Antigens
• CD8 Antigens
• Candida albicans
• Cryptococcus neoformans
• Cytotoxicity, Immunologic
• Schistosoma
• Signal Transduction
• T-Lymphocytes, Cytotoxic
• Toxoplasma

Digital Object Identifier (DOI)

• 10.1155/2010/249482

start page

• 1

end page

• 9

volume

• 2010