POZ for effect – POZ-ZF transcription factors in cancer and development Journal Articles

abstract

• The BTB/POZ-ZF [Broad complex, Tramtrack, Bric à brac (BTB) or poxvirus and zinc finger (POZ)-zinc finger] protein family comprises a diverse group of transcription factors. POZ-ZF proteins have been implicated in many biological processes, including B cell fate determination, DNA damage responses, cell cycle progression and a multitude of developmental events, including gastrulation, limb formation and hematopoietic stem cell fate determination. Consequently, dysfunction of vertebrate POZ-ZF proteins, such as promyelocytic leukemia zinc finger (PLZF), B cell lymphoma 6 (Bcl-6), hypermethylated in cancer 1 (HIC-1), Kaiso, ZBTB7 and Fanconi anemia zinc finger (FAZF), has been linked directly or indirectly to tumorigenesis and developmental disorders. Here, we discuss recent advances in the POZ-ZF field and the implications for the design of future studies to elucidate the biological roles of these unique transcription factors.

authors

• Kelly, Kevin F
• Daniel, Juliet

status

• published 

publication date

• November 2006

has subject area

• 06 Biological Sciences (FoR)
• 11 Medical and Health Sciences (FoR)
• Animals (MeSH)
• Developmental Biology (Science Metrix)
• Gene Expression Regulation, Developmental (MeSH)
• Gene Expression Regulation, Neoplastic (MeSH)
• Growth and Development (MeSH)
• Humans (MeSH)
• Neoplasms (MeSH)
• Transcription Factors (MeSH)
• Zinc Fingers (MeSH)

published in

• Trends in Cell Biology  Journal

keywords

• Animals
• Gene Expression Regulation, Developmental
• Gene Expression Regulation, Neoplastic
• Growth and Development
• Humans
• Neoplasms
• Transcription Factors
• Zinc Fingers

Digital Object Identifier (DOI)

• 10.1016/j.tcb.2006.09.003

PubMed ID

• 16996269

start page

• 578

end page

• 587

volume

• 16

issue

• 11